Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

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Alopecia mucinosa

It may persist for months or years and no specific therapy has been found to be effective for patients with idiopathic alopecia mucinosa. The lesions of Alopecia mucinosa tend to persist for months or years and may show spontaneous clearing, however, in general the therapy for alopecia mucinosa remains nonspecific as no single agent has been shown to consistently improve this condition. Mucinisa presence of lesional skin T-cell clonality in FM does not portend a poorer prognosis.

The treatment was, however, started a month later as she was in her village for the summer holidays. Follicular mucinosis responding to dapsone. Discontinue therapy or consider slow titration over months or years after complete response is evident.

Follicular Mucinosis (Alopecia Mucinosa)

By using this site, you agree to the Terms of Use and Privacy Policy. In any subtype of FM, lesional skin polymerase chain reaction PCR based molecular testing for T-cell clonality may be positive, thereby suggesting monoclonality of the infiltrating T lymphocytes.

Images hosted on other servers: This page was last edited on 21 Juneat He gave a history of childhood atopic dermatitis with mild asthma but was off all medications since several years.


These lesions had persisted for months, had even grown in size in case 2, and not responded to topical steroids and tretinoin in case 3. Therefore it is too much of coincidence to consider that the response in all patients was due to natural remission, and it is most likely that it was the oral treatment that brought about healing of the lesions.

Report of four cases not responsive to minocycline.

Alopecia Mucinosa Responding to Antileprosy Treatment: Are we Missing Something?

From Wikipedia, the free encyclopedia. Follicular mucinosis as a histological finding by itself, does not denote a specific clinico-pathological entity and has been described as an incidental finding in several unrelated conditions like angiolymphoid hyperplasia,[ 56 ] familial reticuloendotheliosis,[ 7 ] spongiotic dermatitis,[ 1 ] and in diffuse papular and eczematous eruptions. The objective of this paper is to draw attention to an unusual finding, that is, rapid and a,opecia response of Alopecia mucinosa to antileprosy treatment with no subsequent relapse over fairly long periods of posttreatment observation.

Isotretinoin is pregnancy category X.

While response to dapsone in the first six cases and minocycline in the last case is possible, the most consistent common factor in all cases seems to be antileprosy treatment. Folliculitis Folliculitis nares perforans Tufted folliculitis Pseudofolliculitis barbae Hidradenitis Hidradenitis suppurativa Recurrent palmoplantar hidradenitis Neutrophilic eccrine hidradenitis. Lever’s Histopathology of the skin. National Center for Biotechnology InformationU. In patches of early leprosy granulomas may be absent and lymphocytes may be seen infiltrating the epidermis and follicular epithelium and arrector pilorum muscles.

J Cut Med Surg. Primary or idiopathic Alopecia mucinosa was first described in by Pinkus. If you have any concerns with your skin or its treatment, see a dermatologist for advice.


Some treatments that have been tried with limited success include:. New author database being installed, click here for details. Few of the follicular infundibula showed features of follicular mucinosis with mild spongiosis, separation of the keratinocytes from one another, and clear spaces between the keratinocytes, which contained wisps of light blue-gray mucin.

For solitary or localized lesions, topical agents are first line because they are low risk, easy to administer, and low cost.

In this article mucinos describe three cases, two children with a single facial lesion clinically suspected to be leprosy in whom biopsy showed follicular mucinosis without granulomas.

Alopecia mucinosa | DermNet NZ

The biopsy showed a moderately dense superficial and mid perivascular infiltrate of lymphocytes with occasional alopeci without any granulomas in the sections. Etiology The etiology is not known. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

Alopecia mucinosa is a clinic-pathological entity which presents with several erythematous papules and plaques mainly over the head and face regions with associated loss of hair and histopathological findings of follicular mucinosis affecting most of the follicles. D ICD – No reliable distinguishing clinical, histological, or molecular parameter exists.

Home About Us Advertise Amazon. Immunohistochemistry showed the infiltrating lymphocytes to be CD3 and CD4 positive.

Long-term dermatologic follow up is necessary; a reasonable frequency for skin and lymph node exam is every months initially, then annually.