Carbapenems (eg, imipenem, meropenem) and the monobactam antibiotic aztreonam are generally reserved for serious infections caused by. Meropenem – Download as PDF File .pdf), Text File .txt) or read online. antibiotik Meropenem. Copyright: © All Rights Reserved. Download as PDF, TXT or. , Meropenem45, MEM, 10 mcg, 10/SP. , Metronidazole78, MET, 80 mcg, 10/SP. , Mezlocillin46, MZ, 75 mcg, 1/EA.

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From Wikipedia, the free encyclopedia. In a review of 20 clinical studies, the combination of an aminoglycoside and a carbapenem had the lowest mortality rate By using this site, you agree antiiotik the Terms of Use and Antjbiotik Policy. This page was last edited on 4 Novemberat Resistance to penems of Natibiotik, Pseudomonas aeruginosa and Acinetobacter spp.

Discontinuation of therapy with meropenem and the administration of specific treatment for Clostridium difficile should be considered. Marketing authorisation number s 9. However, combination therapy may still be warranted due to the potential for the emergence of resistance.

Combination therapy for carbapenem-resistant Gram-negative bacteria. Treatment of carbapenem-resistant Klebsiella meroepnem Loading and maintenance doses and dosing interval in table based on the largest pharmacokinetic studies to date, which developed the first scientifically based dosing suggestions for colistin and polymyxin B [ 3132 ].

Appropriate antimicrobial therapy OR, 0. Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity see section 5.

Abbreviations | Antibiotic & Antimicrobial Resistance Surveillance

It is interesting to note that meropenem, colistin, tigecycline antibiotki was associated with a significant reduction in mortality, even in patients who received inappropriate empiric therapy then this combination as definitive therapy.


There is no target-based cross-resistance between meropenem and agents of the quinolone, aminoglycoside, macrolide and tetracycline classes.

Antimicrobial resistance is globally recognized as one of the greatest threats to public health. Biotransformation Meropenem is metabolised by hydrolysis of the beta-lactam ring generating a microbiologically inactive metabolite. Seizures have infrequently been reported during treatment with carbapenems, including meropenem see section 4.

β-lactam antibiotic

In addition, despite in vitro susceptibility, on-treatment resistance emergence has been described [ meropenwm43 ]. In case reports, ertapenem plus either doripenem or meropenem has been used successfully to treat select pandrug-resistant and colistin-resistant KPC-producing K pneumoniae infections bacteremia, VAP, and UTI.

EnterobacteriaceaePseudomonas aeruginosa, Acinetobacter spp. There are several potential advantages to the antlbiotik of polymyxin B over colistin, many of which stem from the fact that colistin is administered as the inactive prodrug colistimethate CMS. Antibiotic resistance threats in the United States, The selection of meropenem to treat an individual patient should take into account the appropriateness of using a carbapenem antibacterial agent based on factors such as severity of the infection, the prevalence of resistance to other suitable antibacterial agents and the risk of selecting for carbapenem-resistant bacteria.

This article antiblotik been cited by other articles in PMC.

β-lactam antibiotic – Wikipedia

In vitro meropenem shows reduced susceptibility to hydrolysis by human dehydropeptidase-I DHP-I compared to imipenem and there is no requirement to co-administer a DHP-I inhibitor. In a review which included 24 cases of aminoglycoside combination therapy most often with colistin, carbapenems, fluoroquinolones, and tigecyclineall patients who failed aminoglycoside-based combination therapy had bloodstream infections [ 68 ]. This medicinal product contains approximately 4 mEq of sodium per 1 g dose which should be taken into consideration by patients on a controlled sodium diet.

Infection Source Empiric Treatment: Renal dose adjustments are necessary for colistin and CMS but are not required polymyxin B [ 29 ]. Caution is required if probenecid is co-administered with meropenem.


Infrequent adverse effects include fever, vomiting, erythemadermatitis, angioedemapseudomembranous colitis. In the first study, all patients who received combination therapy had favorable outcomes, whereas Outside the United States, IV fosfomycin has been used for a wide range of infections including bacteremia, osteomyelitis, and meningitis at daily doses of 1—16 g divided in 3 or 4 doses.

Definitive combination therapy OR, 0.

In other projects Wikimedia Commons. However, continued research is desperately needed, in particular randomized controlled trials, to determine the most appropriate treatment for serious CRE infections. There is no dose adjustment necessary see section 4.


Retrieved antkbiotik ” https: Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Monotherapy resulted in mortality rates that were not significantly different from those in patients treated with inappropriate therapy with no in vitro active agents Viridans group streptococci 2. Hefny Pharma Group [16]. The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP.

Adverse events associated with intravenous fosfomycin.

Tobramycin b Bactericidal concentration dependent ; protein synthesis inhibition at 30S ribosomal subunit fCmax: Pharmacy and pharmacology portal Medicine portal.

The mean meropenem clearance values were 5. meorpenem

Medicinal products that inhibit peristalsis meropenfm not be given. Inhibit peptidoglycan subunit synthesis and transport: Accumulates in the intracellular and tissue compartments rapidly after IV infusion.

Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem.

Company contact details Pfizer Limited.