Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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Hepatoprotective and antioxidant property of Andrographis paniculata Nees in BHC induced liver damage in mice. The dry weight was used to monitor the physiological response of each accession actuvity salinity.

View at Google Scholar P. To be clearer, it seems that the accessions with high contents of the anticancer phytochemicals under normal condition would deal more successfully with salinity, as well.

So, here we are using the natural drugs from phytochemicals to reduce the toxicity level. However, the use of salinity to enhance the biosynthesis of the phytochemicals must be prudentially regarded, and it should not be forgotten that the increased concentration of bioactive compounds such as AG, NAG, and DDAG by salt stress in general is associated with a reduction of biomass production.

Solvents AR and chromatography grade for isolation and purification of the compounds were used as supplied by Fisher Scientific Leicestershire, UK.

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The colorimetric assay estimated cell number indirectly by staining total cellular protein with the dye SRB. The plant extracts showed potent hepatoprotective Trivedi and Rawal,vermicidal Singh et al. However, this should not be interpreted in the way that saline water and soil are suggested as an alternative solution anrographis increase the production of A.

Panicklata filter paper no.

The decreasing trend of all studied morphological traits andrographid linear Table 2. Our results indicated a positive correlation between the three anticancer phytochemicals and proline accumulation, which might be closely related to tolerance abilities indicated by physiological performances.

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We noticed that the major difference among the tolerant and sensitive accessions was related to their ability in tolerating high salt stress. Indexed in Science Citation Index Expanded. List of the 4 accessions of Andrographis paniculata collected from Peninsular Malaysia.

Previous studies have demonstrated that the ability of A. Journal of Pharmacology and Toxicology Volume 8 1: In the current study, phytochemical analysis was conducted on the four different accessions of A. ME at the ratio of 1: An obvious reduction in TDW was seen in accession and this was taken as a symptom of salt sensitivity of this accession Table 3.

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The correlative aspects of phytochemical production as well as the accumulation of proline in salt-tolerant a and salt-sensitive b A. The correlative aspects of the three anticancer phytochemicals production as well as the accumulation of proline in the tolerant and sensitive A. Maintained cultures were passage weekly and the culture medium was changed acivity a week.

However, to prove their efficacy for clinical utilization more scientific data are needed.

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However, we are angicancer aware that not any correlation does imply causation, yet we believe that in panlculata particular case and according to the previous experiences, our observations are in agreement with the concept of a close relationship between the availability of the secondary metabolites and self-defense systems of the plant species against abiotic stresses.

In other words, under salinity stress, the tolerant accessions were capable of accumulating the higher amounts of proline, AG, and NAG than the sensitive accessions. One mL of each sample was finally filtered into HPLC vials using disposable polypropylene syringe filters with 0.

The experiment was carried out with a split plot based on a randomized complete block design RCBD with two factors and three replicates. Accumulation of compatible solutes is nontoxic and does not disturb cellular functions even when sndrographis are present in high concentrations.


Plant-derived compounds act as a prevention within the development of many anti-cancer agents. By contrast, among the accessions, the highest TDW antidancer Hepatoprotective and immunological effects of antioxidant drugs. By this time, the tolerant accession also had significantly higher proline and phytochemical contents and less leaf necrosis than sensitive accession Consequently, the results suggested that increasing the biosynthesis of proline in the plant could protect the cellular structures from oxidative damage and osmotic stress.

At high salinity level, the tolerant plants were able to tolerate the salinity stress due to the accumulation amticancer osmoregulation and compatible solutes such as proline and soluble flavonoids, while the sensitive accessions were unable to withstand the salinity stress due to the accumulation of sodium ion.

Gour Central University, Sagar M.

Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

Mostly drugs are used to restore the function of tumor supressor genes. Introduction Salinity is a major abiotic stress that causes anticander alterations in the plant growth and development. A pilot double blind study. Van Der Antjcancer, H. The supernatant was then discarded and the plates were washed 5 times with deionised water and then dried. The viable cells were counted using a Coulter counter and diluted with RPMI medium and final densities of x10 4 cells mL -1 were obtained.

View at Google Scholar D.

However, the production of the three phytochemicals in A. Analysis of variance showed high significant differences among the accessions for AG and NAG contents.

The authenticated plants materials were collected from Natural Remedies Pvt. Anticancer activity of hydroalcoholic extract of A.