Épissage constitutif et alternatif. A) Schéma d’un événement d’épissage. L’intron excisé mène à la production d’un ARNm mature qui est exporté au cytoplasme. d’une dizaine d’éléments contrôlant l’épissage alternatif des exons mutuellement exclusifs IIIb et IIIc de FGFR2 ont été identifiés (figure 3A). Bien que les. Causes d’altération de l’épissage alternatif dans les cancers. A) Mutations affectant l’épissage alternatif et quelques exemples de gènes ayant subi ce type de.
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This regulation is under control of the spliceosome and several splicing factors are also required to modulate the alternative usage of splice sites.
Abstract Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at lower levels than the last exon of genes.
Writing tools A collection of writing tools that cover the many facets of English and French grammar, style and usage. Glossaries and vocabularies Access Translation Bureau glossaries and vocabularies. Most of protein-coding human epissahe are subjected to alternative pre-mRNA splicing.
Epissage Alternatif by Peter Oriane on Prezi
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Splicing factors and spliceosome components recognize splicing signals and regulatory sequences of the pre-mRNAs. HuR binding to the alternative 3′-terminal exon in the pre-messenger RNA promotes its splicing, and is eissage by topoisomerase inhibitors.
Current usage metrics About article metrics Return to article. FAQ Frequently asked questions Display options. A collection of writing tools that cover the many facets of English and French grammar, style and usage. Link to PubMed entry. Services Articles citing this article CrossRef 2. This mechanism is highly regulated to precisely modulate detection of specific splice sites.
These findings provide new insights into the evolution, function andmolecular regulation of alternative 3′-terminal exons. These splicing sequences make splicing susceptible to polymorphisms and mutations. Metrics Show article metrics.
Altérations de l’épissage et maladies rares | médecine/sciences
Following growing of knowledge regarding splicing regulation, several approaches have been developed to compensate for the effect of deleterious mutations and to restore sufficient amounts of functional protein. The generation of two or more different mature mRNA’s from the same primary transcript through variation in the sites of splicing. Data correspond to usage on the plateform after The current usage metrics is available hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while. Wlternatif is a method of producing episwage and functionally distinct proteins from the same gene and a method of developmental regulation.
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Alternative splicing and tumor progression
Info A recently evolved class of alternative 3′-terminal exons involved in cell cycle regulation by epossage inhibitors.
Previous article Next article. Here we discover a class of human genes, in which the last exon appeared recently during evolution, and the major gene product uses an alternative 3′-terminal exon corresponding to the ancestral last exon of the gene. Although many alterations are caused by mutations in splicing sequence i. This novel class of alternative 3′-terminal exons are downregulated on a large scale by doxorubicin, a cytostatic drug targeting topoisomerase II, and play a role in cell cycle regulation, including centromere-kinetochore assembly.
Alternative 3′-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at lower levels than the last exon of genes.
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