Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Young birds ( weeks). Causes: Infectious bursal disease virus . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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Subclinical disease occurs in chickens infected before three weeks of age. While it has become clear that amino acids within the variable region of virus protein VP2 account for the molecular basis of antigenic variation, no definite hot spot that determines pathogenicity has been identified.

Low-attenuated vaccine strains may cause damage to the bursa of Fabricius and immunosuppression in susceptible chicks. The table below shows comparative resistance of IBDV with other infectious disease pathogens. The search for such markers is in progress.

Passive immunity may protect against challenge with homologous IBDV, as does previous infection with homologous avirulent djsease.

Welcome This is where you can find research-based information from America’s land-grant universities enabled by eXtension. Investigation of the antigenic evolution of field isolates using the reverse genetics system of infectious bursal disease virus IBDV. This review article bridges the current understanding of IBDV from epidemiological and immunological perspectives, to possible control measures and new developments in prophylactic strategies against IBDV. Besides biosecurity, vaccination is the most important measure to control IBDV in the field.


In birds surviving the acute stage of the disease, the bursa is progressively atrophying. The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus.

Acute infectious bursal disease in poultry: a review.

New alternative prophylactic strategies may be investigated further, including the use of recombinant Abs, recombinant single chain variable fragment Abs, or nanobodies specific for vvIBDV.

Serological tests such as agar gel precipitation and ELISA, for detecting antibodies, are used for monitoring vaccine responses and might be additional information for diagnosis of infection of disdase flocks.

Editor who approved publication: Infectious ij disease Gumboro disease. VP3 also interacts extensively with the viral dsRNA genome.

Classical serotype 1 vaccines still induce good protection, but the actual problem for control of the disease has became the interference of maternally derived antibody in the establishment of the vaccination schedule. Current status of vaccines against infectious bursal disease.

Acute infectious bursal disease in poultry: a review.

Thus, this hypervariable region of VP2 is the obvious target for the molecular techniques applied for IBDV detection and strain variation studies. When administered per os, IBDV can be detected at 8—12 hours post infection in intestinal mononuclear phagocytic cells, which transport the virus to the BF for extensive replication in B-cells.

Virus neutralizing Abs against the conformation dependent neutralizing epitopes can be detected after few days of infection or vaccination and provide protection against antigenetically related viruses.

Among them, VP2 protein contains important neutralizing antigenic sites and elicits protective immune response and most of the amino acid AA changes between antigenically different IBDVs are clustered in the hypervariable region of VP2. Clinical signs of affected birds can include depression and ruffling of feathers, poor or lack of appetite, huddling, unsteady gate, reluctance to rise, and diarrhea sometimes bloody.


Clinically the disease is seen only in chickens older than 3 weeks. Clinical Signs Chicks less than three weeks old do not typically show clinical signs of this disease, but their immune systems can nonetheless be adversely affected, and they are not able to fight off the disease.

Khatri M, Sharma JM. If the bursa is damaged by IBD, the immune system does not function properly. Acta Biochim Biophys Sin Shanghai.

Delayed vaccine virus replication in chickens vaccinated subcutaneously with an immune complex infectious bursal disease gumbboro Try asking one of our Experts. However, the B-cell destruction is usually most severe in subclinically infected young, as virus will destroy a smaller population and most cells in one place the bursa. This work is published and licensed by Dove Medical Press Limited.

Infectious Bursal Disease virus. Smith et al 62 demonstrated higher expression of NK lysin to approximately fold at 4 days post infection dpi compared with virus-free controls suggesting cytotoxic T-cells and NK cells involvement.